HORDB

ID: hor000809
Uniprot ID: A0NDK8
Protein name: Corazonin precursor-related peptide
Gene name: CRZ
Organism: Anopheles gambiae (African malaria mosquito)
Family: Corazonin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: gambiae species complex, Pyretophorus, Cellia (subgenus), Anopheles (genus), Anophelinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity; GO:0071858 corazonin receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0045823 positive regulation of heart contraction
GO CC: GO:0005576 extracellular region

Sequence: SPLSSSSSSPSSSAAMEPLTANQLLASALSSGGLNSLKPSEKALL
Length: 45(35-79)
Propeptide: MLHTRTIALLLVGLVVLVNAQTFQYSRGWTNGKRSPLSSSSSSPSSSAAMEPLTANQLLASALSSGGLNSLKPSEKALLRRFLRNPCDLRVASLLAAAHPTKELFPLAGNSFDSAESAGAAFVLPPFLMDPDESNGGIGGSNLANGRSMEDELRFKRGTATGFSDHRQKIA
Signal peptide: MLHTRTIALLLVGLVVLVNA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000809_AF2.pdb

hor000809_ESM.pdb

Mass:	515985	Formula:	C185H314N50O69S
Absent amino acids:	CDFHIRVWY	Common amino acids:	S
pI:	6.53	Basic residues:	2
Polar residues:	20	Hydrophobic residues:	15
Hydrophobicity:	3.78	Boman Index:	-3774
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	91.33
Instability Index:	7797.11	Extinction Coefficient cystines:	0
Absorbance 280nm:	0